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Ajit Singh Lalit Kumar Gupta Ashok Kumar Khare Asit Mittal CM Kuldeep Manisha Balai 《Indian journal of dermatology》2015,60(5):479-484
Background:
The spectrum of pyoderma changes constantly, and so does the antibiotic susceptibility pattern.Aims:
This study was done to assess the magnitude and clinical patterns of pyodermas, their causative micro-organisms, and the antibiotic susceptibility patterns.Materials and Methods:
Five hundred consecutive, clinically diagnosed and untreated cases of pyoderma, attending the Dermatology OPD of RNT Medical College and MB Government Hospital, Udaipur, from October 2010 to September 2011 were the subjects of this study. A detailed clinical examination, and relevant investigations including bacterial culture and sensitivity, were carried out and recorded.Statistical Analysis:
For statistical analysis of data, the software ‘EPI-INFO Version 6’ was used, and Chi-square (χ2) test was applied.Results:
Of 19576 cases attending skin OPD during the study period, pyoderma was seen in 500 patients; the incidence being 2.55%. Males outnumbered females. The highest number of cases (109; 21.8%) was observed in 1st decade. Lower extremities were the commonest site of predilection. Primary pyodermas outnumbered secondary pyodermas. Furuncle (136; 27.2%) and infectious eczematoid dermatitis (62; 12.4%) were the commonest entities among primary and secondary pyoderma respectively. Staphylococcus aureus was the commonest causative agent in both primary and secondary pyoderma. It showed high susceptibility to amoxycillin + sulbactam, aminoglycosides and cefoperazone, moderate susceptibility to linezolid, while low susceptibility to fluoroquinolones and cephalexin.Conclusion:
Such studies help to assess the changing trend of bacterial infections, their causative organisms and antibiotic susceptibility pattern. 相似文献64.
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James R. Conner Emily Meserve Ellen Pizer Judy Garber Michael Roh Nicole Urban Charles Drescher Bradley J. Quade Michael Muto Brooke E. Howitt Mark D. Pearlman Ross S. Berkowitz Neil Horowitz Christopher P. Crum Colleen Feltmate 《Gynecologic oncology》2014
Objective
This study computed the risk of clinically silent adnexal neoplasia in women with germ-line BRCA1 or BRCA2 mutations (BRCAm +) and determined recurrence risk.Methods
We analyzed risk reduction salpingo-oophorectomies (RRSOs) from 349 BRCAm + women processed by the SEE-FIM protocol and addressed recurrence rates for 29 neoplasms from three institutions.Results
Nineteen neoplasms (5.4%) were identified at one institution, 9.2% of BRCA1 and 3.4% of BRCA2 mutation-positive women. Fourteen had a high-grade tubal intraepithelial neoplasm (HGTIN, 74%). Mean age (54.4) was higher than the BRCAm + cohort without neoplasia (47.8) and frequency increased with age (p < 0.001). Twenty-nine BRCAm + patients with neoplasia from three institutions were followed for a median of 5 years (1–8 years.). One of 11 with HGTIN alone (9%) recurred at 4 years, in contrast to 3 of 18 with invasion or involvement of other sites (16.7%). All but two are currently alive. Among the 29 patients in the three institution cohort, mean ages for HGTIN and advanced disease were 49.2 and 57.7 (p = 0.027).Conclusions
Adnexal neoplasia is present in 5–6% of RRSOs, is more common in women with BRCA1 mutations, and recurs in 9% of women with HGTIN alone. The lag in time from diagnosis of the HGTIN to pelvic recurrence (4 years) and differences in mean age between HGTIN and advanced disease (8.5 years) suggest an interval of several years from the onset of HGTIN until pelvic cancer develops. However, some neoplasms occur in the absence of HGTIN. 相似文献66.
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Transcatheter closure of patent ductus arteriosus using the AMPLATZER™ duct occluder II (ADO II) 下载免费PDF全文
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Eric M. Chand MD Lawrence J. Freant MD Joseph W. Rubin MD CM 《Cardiovascular pathology》1999,8(6):97-338
The majority of cardiac involvement in rheumatoid arthritis (RA) is an incidental finding at postmortem, as less than 3% of patients with RA have clinical cardiac signs or symptoms. Most cardiac involvement in RA involves the pericardium and has been known since Charcot first described an RA patient with pericarditis in 1881. Cardiac involvement takes two different forms: non-specific inflammatory changes and specific granuloma formation. Specific rheumatoid nodules in the heart are an infrequent complication of RA. This is the first case report of a surgically excised heart valve with rheumatoid nodules. A 74-year-old RA patient with a high seropositive rheumatoid factor presented with severe aortic regurgitation and underwent a valve replacement. The native aortic valve showed significant stenosis with multiple, classic rheumatoid nodules. Cardiovas Pathol 1999;8: 333–338 相似文献